• Matriptase Exosomes and the Second EGF Signal

  2026-09-02

  The reference study identifies endosomal activation and exosomal release of matriptase as a mechanism that converts an initial EGF–EGFR response into a second, HGF/c-Met-dependent signal promoting skin and breast cancer invasion. Its trafficking-centered model links receptor internalization, acidic protease activation, pro-HGF processing, and tumor-cell motility, providing a framework for studying reciprocal regulation between growth-factor signaling and membrane proteases.

• Bazedoxifene: ER and IL-6/GP130 Research Workflows

  2026-09-02

  Bazedoxifene enables complementary studies of estrogen receptor biology, bone mineral density enhancement, and emerging IL-6/GP130 pathway inhibition. This workflow-focused guide shows how to control solubility, separate receptor signaling from cytotoxicity, and build orthogonal assays for osteoporosis treatment research and cancer-focused repurposing studies.

• FXR Phase Separation Clusters Viral Organelles

  2026-09-01

  The reference study identifies fragile X–related proteins as host factors that organize coronavirus double-membrane vesicles through liquid–liquid phase separation. Its findings connect condensate biology with replication-organelle architecture and suggest experimental strategies for separating organelle clustering, viral RNA synthesis, and translation in mechanistic antiviral studies.

• Rapid Purification of Recombinant Annexin V

  2026-09-01

  Burger and colleagues developed a short purification workflow for recombinant annexin V that combines gentle osmotic opening of Escherichia coli with reversible calcium-dependent liposome binding and final ion-exchange chromatography. The approach produced protein sufficiently pure for crystallography, electron microscopy, spectroscopy, and single-channel measurements, while addressing co-purification problems associated with harsher cell-disruption methods.

• Perifosine Workflows for Akt and Apoptosis Research

  2026-08-31

  Build reproducible Perifosine and KRX-0401 experiments around Akt target engagement, apoptosis, and radiation response. This workflow also shows how to use Akt inhibition as a mechanistic perturbation when studying OM-MSC-mediated protection from cerebral ischemia/reperfusion injury.

• Cepharanthine Inhibits Endometriosis Across Models

  2026-08-31

  A 2026 study evaluated Cepharanthine in endometriotic stromal cells, patient-derived eutopic endometrial organoids, and a murine peritoneal model. The results connect reduced lesion growth with G0/G1 arrest, DNA damage, impaired repair, and mitochondrial apoptosis, while also illustrating how organoids can strengthen preclinical endometriosis research.

• Amikacin as a Transmission-Phenotype Probe

  2026-08-30

  Amikacin and BAY416651 can do more than produce a susceptibility endpoint. This article presents a phenotype-to-transmission framework for interpreting aminoglycoside activity alongside carbapenemase location, plasmid mobility, and clonal dissemination.

• Ampicillin Sodium: From MIC to Mechanism

  2026-08-29

  Ampicillin sodium is a β-lactam antibiotic whose value extends beyond routine growth inhibition. This evidence-led guide connects transpeptidase biology, MIC interpretation, resistance research, and infection-model translation into a more rigorous assay strategy.

• Lactobacillus acidophilus and UDCA in Ulcerative Colitis

  2026-08-28

  Deng et al. show that Lactobacillus acidophilus improves experimental ulcerative colitis partly through microbiota-dependent elevation of ursodeoxycholic acid. The study links this metabolite to coordinated Treg promotion and suppression of M1 macrophage polarization through the RapGap/PI3K-AKT/NF-κB axis, providing a mechanistic framework for probiotic–metabolite therapy.

• Geneticin, G-418 Sulfate: Selection to Translation

  2026-08-28

  Geneticin, also known as G418 Sulfate, is more than a routine selection reagent. Its ribosomal mechanism, resistance-gene logic, and emerging antiviral use provide a framework for building more interpretable cell models and translational workflows.

• Amikacin Sulfate: Intracellular Assay Strategy

  2026-08-27

  Amikacin Sulfate supports rigorous investigation of intracellular non-tuberculous mycobacterial infection. This article presents an assay-design framework inspired by functional metagenomics and clarifies how uptake, bactericidal activity, delivery, and genetic controls should be interpreted together.

• Biotin Azide for Mechanism-Driven Click Assays

  2026-08-26

  Biotin Azide enables selective capture of terminal-alkyne biomolecules through CuAAC, linking bio-orthogonal labeling to sensitive streptavidin-based analysis. This guide shows how Biotin-azide can support assay designs inspired by the Frizzled5–cholesterol–Wnt mechanism while preserving critical controls and biological interpretation.

• NVP-BGJ398 Phosphate: From Signal to Phenotype

  2026-08-26

  NVP-BGJ398 phosphate is a potent FGFR1–3 inhibitor that connects receptor-level pharmacology with cancer and skeletal disease phenotypes. This article explains how to design translational assays around FGFR3 signaling, genetic validation, and tissue-level readouts.

• Griseofulvin: Microtubule Inhibitor for Fungal Research

  2026-08-25

  Griseofulvin is a microtubule associated inhibitor used to study fungal cell mitosis inhibition and microtubule disruption mechanism. The B3680 research product is a solid, approximately 98% pure compound with documented DMSO solubility and recommended storage at -20°C.

• Acifran for Lipid Metabolism Research

  2026-08-25

  Acifran enables controlled HM74A/GPR109A and GPR109B agonism for receptor signaling, cAMP, and lipid-regulation workflows. This guide translates recent cryo-EM findings into practical assay design, comparative receptor testing, and troubleshooting strategies.

8564 records 1/571 page Next 12345 下5页 Last page