• br In order to determine

  2020-01-03

  

  In order to determine the physiological roles of WT (wild type) EWSR1, Dr. Lee\'s group established a conventional Ewsr1 KO mouse [38]. Since then, the Ewsr1 KO (−/−) mouse model has successfully been utilized to decipher many important in vivo roles of EWSR1 (Fig. 1). EWSR1 deficiency alters m

• Importantly a crucial role of transcription factor SP in

  2020-01-03

  

  Importantly, a crucial role of transcription factor SP1 in mediating the anti-lung cancer effect of XJD was found in this study. Our results suggested that the inhibition of SP1 was required to mediate the inhibitory effect of XJD on the growth of NSCLC cells. Nuclear transcription factors SP1 is a

• br Activatable photoacoustic probes Photoacoustic PA imaging

  2020-01-03

  

  Activatable photoacoustic probes Photoacoustic (PA) imaging is a recently developed technique [47]. The imaging approach uses probes that absorb a pulsed laser beam and convert light energy into acoustic signals. It combines the advantages of the high sensitivity offered by optical imaging and th

• BAMB-4 The majority of serpins inhibit serine proteases but

  2020-01-03

  

  The majority of serpins inhibit serine proteases, but serpins that inhibit caspases or papain-like cysteine proteases have also been identified [4], [5]. Inhibitory serpins are ‘suicide’ or ‘single use’ inhibitors that use a unique conformational change to inhibit proteases. This conformational tran

• Although many of the hepatic

  2020-01-03

  

  Although many of the hepatic responses observed on the first day of recovery attenuated over the course of the recovery period, minimal-to-mild centrilobular hepatocellular hypertrophy tended to persist. Mean absolute and relative liver weights had returned to control levels after 28 days of recover

• Introduction CYP is a superfamily of

  2020-01-03

  

  Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I Hordenine in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the metabolism of drugs

• The identification of CCR B

  2020-01-03

  

  The identification of CCR6+ s7694 within the LZ as direct progenitors of MBCs provides a new window into the evolution of immune responses. In practical terms, flow-cytometric detection of CCR6+ GC B cells could provide a means of rapidly assessing vaccine efficacy when applied to fine needle aspir

• MNs can be obtained from

  2020-01-02

  

  MNs can be obtained from iPSCs, using signaling molecules such as retinoic rosmarinic acid (RA) and Sonic hedgehog (Shh) (Table S1).4, 5, 12, 23, 24, 25, 26, 27, 28, 29 These methods rely on developmental principles and require changing the combinations of signaling molecules at multiple steps, whi

• An analysis of EBI expression on dendritic cells DCs

  2020-01-02

  

  An analysis of EBI2 expression on dendritic cells (DCs) showed that EBI2 is highly expressed on CD4+ conventional cDCs. In line with this mice deficient for EBI2 largely lack this subset of cDCs in the spleen. Furthermore, the localization of the residual cells is disturbed [10,11]. It was found tha

• br Multi subunit RINGs There are RING

  2020-01-02

  

  Multi-subunit RINGs There are RING-type E3s that exist as multi-subunit assemblies (see Fig. 3B). A striking example is the Cullin RING Ligase (CRL) superfamily [35], which exhibits enormous plasticity in substrate specificity. Each CRL subfamily is characterized by a cullin protein (Cul-1, 2, 3,

• Sorbitol Immunofluorescence assays were performed to

  2020-01-02

  

  Immunofluorescence assays were performed to localize the enzyme during growth and differentiation to further characterize Giardia E1. As stated before, the assays showed that the Sorbitol generated recognized specific E1 forms (E1-114, E1-90 and E1-67 with anti-gNTE1; and E1-47 with anti-gE1CT); th

• br Acknowledgements br Introduction Lung cancer treatment st

  2020-01-02

  

  Acknowledgements Introduction Lung cancer treatment strategies, especially molecular targeted therapy, have progressed rapidly. However, most established treatments are for adenocarcinoma of the lung, not for squamous cell carcinoma (SQCC). SQCC constitutes approximately 30% of lung cancers, w

• br Results br Discussion The sequence

  2020-01-02

  

  Results Discussion The sequence homology-based clustering of the human kinome by Manning et al. (2002) has been extremely useful to organize kinases into LB Agar Miller by sequence relationship. Since kinases are such prominent drug targets, we expect that clustering of the kinases by their i

• br Transparency document br Acknowledgments This work was su

  2020-01-02

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

• The on target in vitro pharmacology of was then

  2020-01-02

  

  The on target in vitro pharmacology of 18 was then further explored, first in respect of murine CRTh2 receptor activity (Table 5), where similar levels of activity were found in both a binding and functional assay compared with the human orthologue, consistent with our earlier observations in the su

16105 records 903/1074 page Previous Next First page 上5页 901902903904905 下5页 Last page