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The focused set of additional
2022-01-29
The focused set of additional pyrazole analogs allowed the identification of three additional moderately potent γ-secretase modulators, , and which were subsequently screened in a kinetic solubility assay. Unfortunately, neither the architectural changes in analog nor the integration of trifluoro
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We also noticed that acetic acid by itself
2022-01-28
We also noticed that acetic acid by itself (used to induce pain) increased spinal cord levels of KYNA (see Fig. 5). The most rational explanation of this finding is based on the possibility that acetic acid and KYNA share the same transport systems and the finding is therefore not surprising. Altho
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The occurrence of MDR in
2022-01-28
The occurrence of MDR in cancer patients undergoing chemotherapy can be mimicked in the laboratory by culturing cancer Levodopa in the presence of chemotherapeutic drugs, thereby enforcing the evolution of acquired drug resistance. This has been described in multiple model systems including the rha
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br Introduction Lichen forming fungi LFFs have
2022-01-28
Introduction Lichen-forming fungi (LFFs) have evolved in various classes, including Arthoniomycetes, Coniocybomycetes, Dothideomycetes, Eurotiomycetes, Lecanoromycetes, Leotiomycetes and Lichinomycetes, in Ascomycota (James et al., 2006, Schoch et al., 2009a, Lumbsch and Rikkinen, 2017, Prieto et
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Cortisol is a natural glucocorticoid
2022-01-28
Cortisol is a natural glucocorticoid hormone produced by the adrenal cortex. Its secretion is stimulated by the sympathetic nervous system, and its main function is to mobilize energy to protect the homeostasis of vital biochemical processes during physical and psychological stress [14]. Chronic lev
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Glucagon regulates the transition from hepatic glucose utili
2022-01-28
Glucagon regulates the transition from hepatic glucose utilisation in the absorptive state to glucagon production in the post-absorptive state by acute stimulation of glycogenolysis and inhibition of glycolysis [1]. An important component of this response is the phosphorylation of liver PFK2/FBPase2
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br Materials and methods br Results br
2022-01-27
Materials and methods Results Discussion Defective regulation and inappropriate activation of the HH signaling pathway is implicated in many cancers. SMO targeting inhibitors were the first to enter clinical trials, however complications with acquired resistance and toxicity, also exemplifi
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br Summary br Conflict of interest br Acknowledgments
2022-01-27
Summary Conflict of interest Acknowledgments This study was supported by Grant No. 2014/13/B/NZ7/02277 from the National Science Centre, Poland. Introduction Progesterone (P) is an anticonvulsant hormone (Backstrom et al., 1984, Herzog, 1995, Herzog, 1999, Frye et al., 2000, Reddy, 2002
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G quadruplex structures can be resolved by helicases Consist
2022-01-27
G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer Ticlopidine HCl [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovere
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FBPase deficiency is a very rare inborn error
2022-01-27
FBPase deficiency is a very rare inborn error of fructose 99 0 of autosomal recessive inheritance. This disorder usually occurs in the first year of life through ketotic hypoglycemia and lactic acidosis triggered by catabolic episodes such as prolonged fasting or febrile infections (Steinmann et al
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Recent findings of us suggest that compounds
2022-01-27
Recent findings of us suggest that compounds that inhibit both FAAH and TRPV1 may be more efficacious in pain relief than those targeting only one such protein. As continuation of our efforts to identify new molecules able to target simultaneously both FAAH and TRPV1 receptors, we hypothesized that
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Management of HIV treatment with HIV PIs
2022-01-27
Management of HIV-1 treatment with HIV PIs can be complicated due to wide inter-patient variability in palmitic acid levels. In certain scenarios, therapeutic drug monitoring (TDM) has been recommended as a useful approach to individualize therapy for HIV-infected patients [[9], [10], [11], [12]].
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On the other hand imidazolylcyclopropane derivatives
2022-01-27
On the other hand, imidazolylcyclopropane derivatives and having a 2-substituted benzimidazolyl group showed moderate binding affinities for both the HR and HR. Replacement of 4-chlororbenzylamino group of with a benzimidazolyl group () led to increase the affinity for the HR more than 5-fold ( =
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luciferin definition australia br STAR Methods br Acknowledg
2022-01-27
STAR★Methods Acknowledgments We thank P. Adler, V. Riechmann, N. Tapon, E. Knust, the Vienna Drosophila RNAi Center, the Australian Drosophila Research Support Facility (www.ozdros.com), the Bloomington Drosophila Stock Center, and the Developmental Studies Hybridoma Bank for D. melanogaster s
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Transcriptional elongation is a checkpoint for productive tr
2022-01-27
Transcriptional elongation is a checkpoint for productive transcription. In ESCs, ∼50% of the genes enriched for H3K4me3 are initially transcribed but do not enter productive elongation (Guenther et al., 2007, Rahl et al., 2010). Following promoter escape, the transcriptional elongating protein comp
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