• Generally histone modifications facilitate protein protein i

  2018-11-06

  

  Generally, histone modifications facilitate protein–protein interactions with effector proteins or readers. Bromodomains interact with acetyl-lysines, while chromodomains, plant homeodomains (PHD), and others associate with methyl-lysines. Interestingly, H2AZ-containing nucleosomes associate with se

• An alternative approach would be to identify successful

  2018-11-06

  

  An alternative approach would be to identify successful examples of organ regeneration in nature, dissect their mechanisms, and then attempt to apply gained insights to humans via the provision of the appropriate regenerative stimuli. Urodele amphibians and teleosts are well-known examples of animal

• In accordance with our previous observations Salazar et

  2018-11-06

  

  In accordance with our previous observations (Salazar et al., 2010), hCSN-SCns transplanted at the early-chronic stage of SCI exhibited migration away from the injury epicenter, as well as a preferential rostral localization in migration and proliferation. These data may suggest that extrinsic facto

• br Materials and methods br Verification and authentication

  2018-11-06

  

  Materials and methods Verification and authentication To confirm iPS cell identity and purity, we showed the positivity for the alkaline phosphatase and for the expression of pluripotency markers both by immunofluorescence and by RT-PCR (Fig. 1C-F). Acknowledgements This work was supported

• Micro array data has been

  2018-11-06

  

  Micro-array data has been submitted to Gene Expression Omnibus with GEO accession number: GSE72118. Competing financial interests Acknowledgements Introduction Recent studies in the stem cell field have demonstrated that cell fate transition could be achieved by introducing lineage-specifi

• ABT888 Indeed both hAT MSC and hiPS

  2018-11-06

  

  Indeed, both hAT-MSC and hiPS-MSC baACL implants, when validated in a swine ACL excision model, resulted in proper ACL tissue formation. In the osseous zones, both in the tibia and the femur, the fibres of the biomaterial were surrounded by newly formed tissue that was encapsulated within mature bon

• br Results br DAPT Enhances MEF C Binding to

  2018-11-05

  

  Results DAPT Enhances MEF2C Binding to Cardiac Gene Promoters Notch activation is known to impair myoblast differentiation (Shen et al., 2006; Wilson-Rawls et al., 1999). We previously showed that this effect is due, at least in part, to the interaction of NICD with the MEF2C DNA binding domai

• Go 6983 br Results br Discussion We generated a library

  2018-11-05

  

  Results Discussion We generated a library of iPSCs from patients with sickle cell anemia of diverse ethnicities and HBB haplotypes to study the biology of these Go 6983 and the feasibility of their generation from blood samples collected from patients in distant locations and shipped frozen t

• Global gene expression of RB null teratomas revealed an

  2018-11-05

  

  Global gene expression of RB1-null teratomas revealed an upregulation of neural-related genes and a depleted expression of epidermal tissue-related genes. As both the nervous system and the epidermis originate from the ectoderm, these results suggest that the RB1 ablation could alter early ectoderma

• br It is particularly interesting to compare neural network

  2018-11-05

  

  It is particularly interesting to compare neural network solutions constructed using various types of complementary data at specific values of the root-mean-square error. Fig. 2 shows neural network approximations for the models with the parameters m = 20, = 0 without applying the asymptotic cond

• Introduction The materials used to fabricate thermoelectric

  2018-11-05

  

  Introduction The materials used to fabricate thermoelectric generators and coolers must meet various requirements related to their cheapness, environmental safety and reliability. However, all of them should have a high thermoelectric figure of merit ZT (T is an absolute temperature). The thermoele

• There is a growing interest in the impact of

  2018-11-05

  

  There is a growing interest in the impact of stress including cumulative adversity over the lifetime, and the physiological toll resulting from ongoing activation of stress responses at or around the time of childbearing (Phelan et al., 2015; Hobel, Goldstein, and Barrett, 2008; Dominguez et al., 20

• The specific sources of data for each section of

  2018-11-05

  

  The specific sources of data for each section of the paper are described in Appendix A. Results Discussion From the above observations we draw a series of ten inferences, presented roughly in the order of those least to most speculative; since we have offered no identification strategy in the

• Models and focus on educational differentials in health Firs

  2018-11-05

  

  Models 4 and 5 focus on educational differentials in health. First, Model 4 shows a positive association between higher education and good SRH. Then, random effect of education, estimated with a cross-level interaction (education×year), is reported in the bottom of Model 5. Random effect of educatio

• br Introduction The obesity epidemic has been

  2018-11-05

  

  Introduction The obesity epidemic has been linked to a web of interdependent causes operating at multiple cascading levels (Galea, Riddle, & Kaplan, 2010; Glass & McAtee, 2006; Huang, Drewnosksi, Kumanyika, & Glass, 2009) including environmental influences, genetics, cultural preferences, environ

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