• In addition while a general biomarker hypothesis was stated

  2018-11-09

  

  In addition, while a general biomarker A 779 was stated in the protocol, the specific biomarker (i.e., HRG mRNA) and a description of the validated assay were defined only in the statistical analysis plan. An alternative approach would have been to amend the protocol once the preclinical data and a

• In this study we investigated changes

  2018-11-09

  

  In this study, we investigated changes in MMP concentrations on ART and the association between these changes and paradoxical TB-IRIS in a well-characterized cohort of HIV-infected adults with advanced HIV/TB (Ravimohan et al. 2013; Ravimohan et al. 2015a). Furthermore, in a subset of patients, we e

• A potential detection method is

  2018-11-08

  

  A potential detection method is to analyze the air within a grain mass for specific volatile compounds (VOCs) released by insects. In recent years, headspace solid phase microextraction (HS-SPME) in conjunction with gas chromatography–mass spectrometry (GC–MS) has been employed to examine volatile c

• WP 1130 manufacturer br Concluding remarks Overall the achie

  2018-11-08

  

  Concluding remarks Overall, the achievements in food toxicology in the last decades have been significant gaining a deeper understanding of the molecular mode of action by which toxic effects are induced. These mechanistic insights have helped to identify potential toxicants thus enhancing food s

• Introduction Botulinum neurotoxins BoNTs composed of seven

  2018-11-08

  

  Introduction Botulinum neurotoxins (BoNTs), composed of seven biochemically distinct serotypes (BoNT/A–G) secreted by d-glucose bacteria Clostridium botulinum, are extremely potent inhibitors of neurotransmitter exocytosis at neuromuscular junctions (Neale et al., 1999; Rossetto et al., 2006; Mont

• The concept of hematopoietic stem cells More than a

  2018-11-08

  

  The concept of hematopoietic stem cells: More than a century ago The development of cell biology research coincides with the advance of microscopes in the 19th century. It was finally possible to directly observe the various blood cell types and to witness their proliferation and differentiation (M

• br Long term maintenance of hPSCs in a scalable

  2018-11-08

  

  Long term maintenance of hPSCs in a scalable and defined suspension culture system A report published recently in Stem Cell Research (Chen et al., 2012, 8:388–402) extends from these previous studies to demonstrate for the first time, the long term expansion of hESCs retaining the characteristic

• Although our work with BRCA mutant iPSCs led to our

  2018-11-08

  

  Although our work with BRCA1 mutant iPSCs led to our investigation of PKC-theta upregulation in human breast tumors, future studies will be necessary to validate whether PKC-theta can be used as a biomarker or therapeutic target in BRCA1 mutant tumors. Because the frequency of BRCA1 mutations in pat

• Differentiation of HD ESCs had only a minor

  2018-11-08

  

  Differentiation of HD ESCs had only a minor effect on repeat expansion; this was as expected considering the low level of somatic expansion found in most tissues. We did, however, find that differentiation status influenced the effect introduced oxidative DNA damage had on CAG expansion. Mouse model

• Parkinson s disease PD is a neurological disorder

  2018-11-08

  

  Parkinson\'s disease (PD) is a neurological disorder characterized by the degeneration of dopaminergic neurons in the midbrain substantia nigra, leading to a reduction of dopamine in the striatum (Gaillard and Jaber, 2011). Currently, dopaminergic neurons can be obtained through differentiation from

• To investigate whether PD derived HSCs

  2018-11-08

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• PDGs possess a specific architecture and

  2018-11-08

  

  PDGs possess a specific architecture and molecular signature that make them distinct from the pancreatic epithelium, instead resembling gastric stem cell glands. PDGs were also found to express and up-regulate TFF genes during injury. In the stomach TFF1 is normally found predominantly in the epithe

• An EMBO conference on cell therapy and its clinical

  2018-11-08

  

  An EMBO conference on cell therapy and its clinical applications The topics Given the broad and sometimes ill-defined distinctions among the various disciplines, we decided to focus on both allogeneic and autologous genetically corrected cell therapy, with the exclusion of “in vivo” gene therapy

• miR expression was strikingly down

  2018-11-08

  

  miR-410 expression was strikingly down-regulated in the adult SVZ following Noggin over-expression in our inducible transgenic mice (Morell et al., 2015). Noggin was initially characterized by its ability to rescue the phenotype of UV light-dorsalized embryos (Smith and Harland, 1992; Lamb et al., 1

• br Materials and methods br Results br Discussion Others

  2018-11-08

  

  Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e

16571 records 1088/1105 page Previous Next First page 上5页 10861087108810891090 下5页 Last page