• br Materials and methods br Author

  2018-10-24

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in t

• A naive state of pluripotency

  2018-10-24

  

  A naive state of pluripotency is functionally defined by the capacity of mouse ESCs to participate in germ layer differentiation and generate germline competent chimeras following their incorporation into host blastocysts (Nichols and Smith, 2009). The naïve cells seem to mimic, although do not comp

• It is thought that a

  2018-10-24

  

  It is thought that a better understanding of the molecular and cellular mechanisms that regulate the emergence and maintenance of long-term repopulating hematopoietic stem Exendin-3 (9-39) amide (HSCs) during embryonic development would aid in the development of optimal protocols to generate such c

• Importantly because none of these markers are

  2018-10-24

  

  Importantly, because none of these markers are specific for trophoblast or trophoblast populations in general, they must be used in combination. For example, SWAN-71 and HTR8/SVneo, two widely used “trophoblast” cell lines, are hypermethylated at the ELF5 promoter, HTR8/SVneo does not express C19MC

• The maturation of human erythroblasts from adult CD

  2018-10-24

  

  The maturation of human erythroblasts from adult CD34+ hematopoietic stem/progenitor 17 alpha hydroxylase (HSPCs) can be assessed by serially tracing the expression of erythroid lineage markers. These markers for adult-type erythroblasts\' developmental process are widely used to recognize hPSC-der

• Introduction The role of chromatin status

  2018-10-24

  

  Introduction The role of chromatin status on DNA damage response (DDR) and DNA double-strand break (DSB) repair has been extensively investigated in differentiated non-stem and cancer cells. Chromatin structure and remodeling plays an important role in the recruitment/assembly of repair factors and

• We assessed levels of cell death

  2018-10-24

  

  We assessed levels of cell death using annexin V and propidium iodide staining. The tp53 animals showed a 20% increase in erythroid cell death when assessed by propidium iodide staining (p = 0.02, Figures 4A and S3A), but no increase in annexin V staining (Figures S3A and S3B), similar to what was o

• tachykinin receptor br Discussion hESCs provide an extraordi

  2018-10-24

  

  Discussion hESCs provide an extraordinary platform for disease modeling, especially for developmental disorders (Avior et al., 2016). We decided to use their unique characteristics to model developmental and tumorigenic aspects of pRB and TRb, a severe neonatal malignancy. Using gene editing, we

• Other parameters listed in the table

  2018-10-24

  

  Other parameters, listed in the table, describe the so-called dechanneling length [1], i.e. the average distance traveled by a positron in channeling mode. The parameter is defined as the average distance traveled by a trapped particle from entering the crystal until exiting the channel. In other wo

• Expansion is a canonical white noise expansion in terms of

  2018-10-24

  

  Expansion is a canonical white-noise expansion in terms of a wavelet basis, i.e., it is a sum of random quantities multiplied by determinate time-varying functions, in this case, wavelet ones. Amiantov\'s study proved, in particular, the assumption that the probability density functional takes the

• where is some parameter eigenvalue A B C

  2018-10-24

  

  where β is some parameter (eigenvalue); A, B, C and D are the unknown coefficients. The general solution of the problem is expressed by the sum The coefficients A, B, C and D in formula (16) are determined from the boundary conditions at the longitudinal edges: y=0 and y=1. Satisfying the condi

• ap-1 transcription factor The second possibility of the elec

  2018-10-24

  

  The second possibility of the ap-1 transcription factor return into the internal d-orbitals of Fe3+ and its transition to the state with spin of 4/2 is the excitation of a non-equilibrium electron and a non-equilibrium hole by the photon as it usually occurs in semiconducting crystals. The free ele

• protease inhibitors hiv Scale similarity criteria the Raylei

  2018-10-24

  

  Scale similarity criteria (the Rayleigh number and the rotation parameter, constructed from the scale quantities) specified in the course of the simulations, were determined for the conjugate and the non-conjugate settings as follows: where ΔT0 is the temperature difference (ΔT0=–). In the conjuga

• At present it is not clear whether

  2018-10-23

  

  At present, it is not clear whether prostaglandins other than PGE-M could also serve as prognostic or predictive biomarkers for colorectal cancer. To examine this, Li et al. took blood samples from healthy individuals, as well as from patients with familial adenomatous polyposis (FAP, an inherited p

• Conflicts of interest br Introduction The goal of islet tran

  2018-10-23

  

  Conflicts of interest Introduction The goal of islet transplantation is to use the donor β-cells to restore the insulin production and glycemic regulation in patients with type 1 diabetes to avoid serious complications (Barton et al., 2012; Goland and Egli, 2014). For long-term graft survival,

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