• ap4 br Bioactive peptides on NO bioavailability and

  2018-11-06

  

  Bioactive peptides on NO bioavailability and endothelial function Bioactive peptides on inflammation Bioactive peptides as RAS modulators Conclusions Acknowledgements This study was supported by Alberta Livestock and Meat Agency (ALMA) and Natural Sciences and Engineering Research Cou

• It is important to note that for the current signal

  2018-11-06

  

  It is important to note that for the current signal amplification protocols, there is a trade-off between the sensing range and the detection limit. People have to make wise choices of signal amplification protocols for achievement of satisfied sensing range or detection limit. Briefly, for signal-o

• br Materials and methods br Results br

  2018-11-06

  

  Materials and methods Results Discussion Conclusions MesenPRO medium is not a “selective” medium that expands only the immature and/or osteogenic progenitor cells believed to reside within human alveolar periosteal tissue. However, this medium did effectively expand the population of hig

• br Experimental Procedures br Author Contributions br Introd

  2018-11-06

  

  Experimental Procedures Author Contributions Introduction Just as the circulatory system provides nourishment to support tissue and organ function, the larger blood vessels themselves require access to a blood supply to maintain vascular health. The vasa vasorum (Latin: “vessels of the vess

• Although colorectal CSCs Co CSCs were originally

  2018-11-06

  

  Although, colorectal CSCs (Co-CSCs) were originally identified as a small group of CD133+ Phos-tag Biotin BTL-105 present in the primary tumors which exhibited high tumorigenicity in immunodeficient mice (O\'Brien et al., 2007; Ricci-Vitiani et al., 2007), some studies have shown that CD44+ colorec

• Gene expression is regulated by complex coordinated

  2018-11-06

  

  Gene expression is regulated by complex coordinated processes, including chromatin remodeling, post-translational modifications of histones, and incorporation of non-allelic histone variants. The histone variant H2AZ constitutes only a few percents of the total H2A cellular pool (). However, H2AZ is

• Generally histone modifications facilitate protein protein i

  2018-11-06

  

  Generally, histone modifications facilitate protein–protein interactions with effector proteins or readers. Bromodomains interact with acetyl-lysines, while chromodomains, plant homeodomains (PHD), and others associate with methyl-lysines. Interestingly, H2AZ-containing nucleosomes associate with se

• An alternative approach would be to identify successful

  2018-11-06

  

  An alternative approach would be to identify successful examples of organ regeneration in nature, dissect their mechanisms, and then attempt to apply gained insights to humans via the provision of the appropriate regenerative stimuli. Urodele amphibians and teleosts are well-known examples of animal

• In accordance with our previous observations Salazar et

  2018-11-06

  

  In accordance with our previous observations (Salazar et al., 2010), hCSN-SCns transplanted at the early-chronic stage of SCI exhibited migration away from the injury epicenter, as well as a preferential rostral localization in migration and proliferation. These data may suggest that extrinsic facto

• br Materials and methods br Verification and authentication

  2018-11-06

  

  Materials and methods Verification and authentication To confirm iPS cell identity and purity, we showed the positivity for the alkaline phosphatase and for the expression of pluripotency markers both by immunofluorescence and by RT-PCR (Fig. 1C-F). Acknowledgements This work was supported

• Micro array data has been

  2018-11-06

  

  Micro-array data has been submitted to Gene Expression Omnibus with GEO accession number: GSE72118. Competing financial interests Acknowledgements Introduction Recent studies in the stem cell field have demonstrated that cell fate transition could be achieved by introducing lineage-specifi

• ABT888 Indeed both hAT MSC and hiPS

  2018-11-06

  

  Indeed, both hAT-MSC and hiPS-MSC baACL implants, when validated in a swine ACL excision model, resulted in proper ACL tissue formation. In the osseous zones, both in the tibia and the femur, the fibres of the biomaterial were surrounded by newly formed tissue that was encapsulated within mature bon

• br Results br DAPT Enhances MEF C Binding to

  2018-11-05

  

  Results DAPT Enhances MEF2C Binding to Cardiac Gene Promoters Notch activation is known to impair myoblast differentiation (Shen et al., 2006; Wilson-Rawls et al., 1999). We previously showed that this effect is due, at least in part, to the interaction of NICD with the MEF2C DNA binding domai

• Go 6983 br Results br Discussion We generated a library

  2018-11-05

  

  Results Discussion We generated a library of iPSCs from patients with sickle cell anemia of diverse ethnicities and HBB haplotypes to study the biology of these Go 6983 and the feasibility of their generation from blood samples collected from patients in distant locations and shipped frozen t

• Global gene expression of RB null teratomas revealed an

  2018-11-05

  

  Global gene expression of RB1-null teratomas revealed an upregulation of neural-related genes and a depleted expression of epidermal tissue-related genes. As both the nervous system and the epidermis originate from the ectoderm, these results suggest that the RB1 ablation could alter early ectoderma

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