• Differentiation of HD ESCs had only a minor

  2018-11-08

  

  Differentiation of HD ESCs had only a minor effect on repeat expansion; this was as expected considering the low level of somatic expansion found in most tissues. We did, however, find that differentiation status influenced the effect introduced oxidative DNA damage had on CAG expansion. Mouse model

• Parkinson s disease PD is a neurological disorder

  2018-11-08

  

  Parkinson\'s disease (PD) is a neurological disorder characterized by the degeneration of dopaminergic neurons in the midbrain substantia nigra, leading to a reduction of dopamine in the striatum (Gaillard and Jaber, 2011). Currently, dopaminergic neurons can be obtained through differentiation from

• To investigate whether PD derived HSCs

  2018-11-08

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• PDGs possess a specific architecture and

  2018-11-08

  

  PDGs possess a specific architecture and molecular signature that make them distinct from the pancreatic epithelium, instead resembling gastric stem cell glands. PDGs were also found to express and up-regulate TFF genes during injury. In the stomach TFF1 is normally found predominantly in the epithe

• An EMBO conference on cell therapy and its clinical

  2018-11-08

  

  An EMBO conference on cell therapy and its clinical applications The topics Given the broad and sometimes ill-defined distinctions among the various disciplines, we decided to focus on both allogeneic and autologous genetically corrected cell therapy, with the exclusion of “in vivo” gene therapy

• miR expression was strikingly down

  2018-11-08

  

  miR-410 expression was strikingly down-regulated in the adult SVZ following Noggin over-expression in our inducible transgenic mice (Morell et al., 2015). Noggin was initially characterized by its ability to rescue the phenotype of UV light-dorsalized embryos (Smith and Harland, 1992; Lamb et al., 1

• br Materials and methods br Results br Discussion Others

  2018-11-08

  

  Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e

• Main Text We appreciate the

  2018-11-08

  

  Main Text We appreciate the interest that Andersen et al. (2014) have shown in our work on neonatal cardiac regeneration. Their recent paper relates directly to resection methodology first presented by Porrello et al. (2011) and describes a failure to reproduce the observations made in that study r

• We have previously used the distinctive HLA

  2018-11-08

  

  We have previously used the distinctive HLA class I profile of VCT and EVT to characterize BMP-treated hESC (Bernardo et al., 2011). As a further refinement, we now show that we can distinguish between products of different HLA class I loci, particularly HLA-G and HLA-A and -B. With knowledge of the

• protease inhibitors hiv br Experimental Procedures br Author

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported by grants from the Ministerio de Ciencia e Innovación (Grant SAF2012-38914), Plan Nacional de I + D + I, Spain and the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (Grant 2014 SGR229), Depar

• These data are in agreement with prior studies

  2018-11-08

  

  These data are in agreement with prior studies demonstrating that hyaluronan levels play a critical role in determining the site of HSC lodgment/engraftment following transplantation (Avigdor et al., 2004; Ellis et al., 2007, 2009, 2011; Nilsson et al., 2003), and that HSC exhibit preferential engra

• Introduction Regarding acid mine drainage

  2018-11-07

  

  Introduction Regarding gadobutrol mine drainage (AMD), the high concentrations of heavy metals cause major environmental concerns characterized by contamination of various ecosystems due to its leaching capacity and the presence of very active bacteria making it self-perpetuating (Kalin et al., 20

• tizanidine hcl This paper aims to investigate this hypothesi

  2018-11-07

  

  This paper aims to investigate this tizanidine hcl – that oil revenues are reducing the fiscal effort of the benefiting municipalities – through the estimation of an efficient tax production frontier based on Battese and Coelli (1995). We include political variables in the inefficiency equation, wi

• In previous studies the determinants of single victimization

  2018-11-07

  

  In previous studies, the determinants of single victimization are usually identified using samples of data which nevertheless have little geographic coverage. In most cases, the sample is restricted to the population of a large city. For example, Gomes and Paz (2008) used a sample made up of some mu

• br I Las certezas del globalismo

  2018-11-07

  

  I Las certezas del globalismo de finales de siglo que llevaron carboxypeptidase hablar del fin de la historia y la consagración del mercado mundial unificado, fueron cuestionadas por la tormenta financiera que iniciara en 2008 y su secuela de recesión y desempleo masivo que persiste en muchas lati

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